Faculty Profiles

Stephen Gluck, MD
M_MED-NEPH-CORE-GEN
Professor

533 Parnassus Ave, UC Hall
San Francisco, CA 94143
415-476-2172
Stephen.Gluck@ucsf.edu

Education and Training

Location Degree or Training Specialty Date
University of California Los Angeles M.D. School of Medicine 1977

Related Web Sites

Awarded Grants

Project Title Project Number Fiscal Year
PATHOPHYSIOLOGY OF RENAL DISEASE P01DK009976 2005
BIOLOGY OF CELL/CELL COMMUNICATION IN BONE P01AR032087 2003
RENAL GENES, GROWTH FACTORS, DEVELOPMENT AND DISEASE P50DK045181 2003
Recent Articles (55)

Khalkhali-Ellis Z, Abbott DE, Bailey CM, Goossens W, Margaryan NV, Gluck SL, Reuveni M, Hendrix MJ. IFN-gamma regulation of vacuolar pH, cathepsin D processing and autophagy in mammary epithelial cells. J Cell Biochem. 2008 Sep 1; 105(1):208-18.

Lu M, Ammar D, Ives H, Albrecht F, Gluck SL. Physical interaction between aldolase and vacuolar H+-ATPase is essential for the assembly and activity of the proton pump. J Biol Chem. 2007 Aug 24; 282(34):24495-503.

Curtis LM, Gluck S. Distribution of Rab GTPases in mouse kidney and comparison with vacuolar H+-ATPase. Nephron Physiol. 2005; 100(3):p31-42.

Sautin YY, Lu M, Gaugler A, Zhang L, Gluck SL. Phosphatidylinositol 3-kinase-mediated effects of glucose on vacuolar H+-ATPase assembly, translocation, and acidification of intracellular compartments in renal epithelial cells. Mol Cell Biol. 2005 Jan; 25(2):575-89.

Gluck SL. Acid sensing in renal epithelial cells. J Clin Invest. 2004 Dec; 114(12):1696-9.

Lu M, Sautin YY, Holliday LS, Gluck SL. The glycolytic enzyme aldolase mediates assembly, expression, and activity of vacuolar H+-ATPase. J Biol Chem. 2004 Mar 5; 279(10):8732-9.

Chen SH, Bubb MR, Yarmola EG, Zuo J, Jiang J, Lee BS, Lu M, Gluck SL, Hurst IR, Holliday LS. Vacuolar H+-ATPase binding to microfilaments: regulation in response to phosphatidylinositol 3-kinase activity and detailed characterization of the actin-binding site in subunit B. J Biol Chem. 2004 Feb 27; 279(9):7988-98.

Holliday LS, Welgus HG, Hanna J, Lee BS, Lu M, Jeffrey JJ, Gluck SL. Interstitial collagenase activity stimulates the formation of actin rings and ruffled membranes in mouse marrow osteoclasts. Calcif Tissue Int. 2003 Mar; 72(3):206-14.

Lu M, Vergara S, Zhang L, Holliday LS, Aris J, Gluck SL. The amino-terminal domain of the E subunit of vacuolar H(+)-ATPase (V-ATPase) interacts with the H subunit and is required for V-ATPase function. J Biol Chem. 2002 Oct 11; 277(41):38409-15.

Lu M, Holliday LS, Zhang L, Dunn WA, Gluck SL. Interaction between aldolase and vacuolar H+-ATPase: evidence for direct coupling of glycolysis to the ATP-hydrolyzing proton pump. J Biol Chem. 2001 Aug 10; 276(32):30407-13.

Holliday LS, Lu M, Lee BS, Nelson RD, Solivan S, Zhang L, Gluck SL. The amino-terminal domain of the B subunit of vacuolar H+-ATPase contains a filamentous actin binding site. J Biol Chem. 2000 Oct 13; 275(41):32331-7.

Holliday LS, Gluck SL, Slatopolsky E, Brown AJ. 1,25-Dihydroxy-19-nor-vitamin D(2), a vitamin D analog with reduced bone resorbing activity in vitro. J Am Soc Nephrol. 2000 Oct; 11(10):1857-64.

Lee BS, Holliday LS, Krits I, Gluck SL. Vacuolar H+-ATPase activity and expression in mouse bone marrow cultures. J Bone Miner Res. 1999 Dec; 14(12):2127-36.

Lee BS, Gluck SL, Holliday LS. Interaction between vacuolar H(+)-ATPase and microfilaments during osteoclast activation. J Biol Chem. 1999 Oct 8; 274(41):29164-71.

Gluck SL, Lee BS, Wang SP, Underhill D, Nemoto J, Holliday LS. Plasma membrane V-ATPases in proton-transporting cells of the mammalian kidney and osteoclast. Acta Physiol Scand Suppl. 1998 Aug; 643:203-12.

Niessen H, Meisenholder GW, Li HL, Gluck SL, Lee BS, Bowman B, Engler RL, Babior BM, Gottlieb RA. Granulocyte colony-stimulating factor upregulates the vacuolar proton ATPase in human neutrophils. Blood. 1997 Dec 1; 90(11):4598-601.

Holliday LS, Welgus HG, Fliszar CJ, Veith GM, Jeffrey JJ, Gluck SL. Initiation of osteoclast bone resorption by interstitial collagenase. J Biol Chem. 1997 Aug 29; 272(35):22053-8.

Bastani B, Underhill D, Chu N, Nelson RD, Haragsim L, Gluck S. Preservation of intercalated cell H(+)-ATPase in two patients with lupus nephritis and hyperkalemic distal renal tubular acidosis. J Am Soc Nephrol. 1997 Jul; 8(7):1109-17.

Wax MB, Saito I, Tenkova T, Krupin T, Becker B, Nelson N, Brown D, Gluck SL. Vacuolar H+-ATPase in ocular ciliary epithelium. Proc Natl Acad Sci U S A. 1997 Jun 24; 94(13):6752-7.

Bastani B, Gluck S. Adaptational changes in renal vacuolar H(+)-ATPase in the rat remnant kidney. J Am Soc Nephrol. 1997 Jun; 8(6):868-79.

Holliday LS, Dean AD, Lin RH, Greenwald JE, Gluck SL. Low NO concentrations inhibit osteoclast formation in mouse marrow cultures by cGMP-dependent mechanism. Am J Physiol. 1997 Mar; 272(3 Pt 2):F283-91.

Lee BS, Krits I, Crane-Zelkovic MK, Gluck SL. A novel transcription factor regulates expression of the vacuolar H+-ATPase B2 subunit through AP-2 sites during monocytic differentiation. J Biol Chem. 1997 Jan 3; 272(1):174-81.

Sabolic I, Brown D, Gluck SL, Alper SL. Regulation of AE1 anion exchanger and H(+)-ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int. 1997 Jan; 51(1):125-37.

Gluck SL, Iyori M, Holliday LS, Kostrominova T, Lee BS. Distal urinary acidification from Homer Smith to the present. Kidney Int. 1996 Jun; 49(6):1660-4.

Bastani B, Ross FP, Kopito RR, Gluck SL. Immunocytochemical localization of vacuolar H+-ATPase and Cl--HCO3- anion exchanger (erythrocyte band-3 protein) in avian osteoclasts: effect of calcium-deficient diet on polar expression of the H+-ATPase pump. Calcif Tissue Int. 1996 May; 58(5):332-6.

Gluck SL, Underhill DM, Iyori M, Holliday LS, Kostrominova TY, Lee BS. Physiology and biochemistry of the kidney vacuolar H+-ATPase. Annu Rev Physiol. 1996; 58:427-45.

Lee BS, Holliday LS, Ojikutu B, Krits I, Gluck SL. Osteoclasts express the B2 isoform of vacuolar H(+)-ATPase intracellularly and on their plasma membranes. Am J Physiol. 1996 Jan; 270(1 Pt 1):C382-8.

Sires UI, Schmid TM, Fliszar CJ, Wang ZQ, Gluck SL, Welgus HG. Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest. 1995 May; 95(5):2089-95.

Lee BS, Underhill DM, Crane MK, Gluck SL. Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. J Biol Chem. 1995 Mar 31; 270(13):7320-9.

Gluck SL, Nelson RD, Lee BS. Properties and regulation of the renal vacuolar H(+)-ATPase and H(+)-K(+)-ATPase. Curr Opin Nephrol Hypertens. 1993 Sep; 2(5):715-24.

Gluck SL. The vacuolar H(+)-ATPases: versatile proton pumps participating in constitutive and specialized functions of eukaryotic cells. Int Rev Cytol. 1993; 137C:105-37.

Gluck SL, Nelson RD, Lee BS, Wang ZQ, Guo XL, Fu JY, Zhang K. Biochemistry of the renal V-ATPase. J Exp Biol. 1992 Nov; 172:219-29.

Gluck S, Nelson R. The role of the V-ATPase in renal epithelial H+ transport. J Exp Biol. 1992 Nov; 172:205-18.

Gluck SL, Nelson RD, Lee BS. Introduction to the principles and methods of recombinant DNA technology. Semin Nephrol. 1992 Nov; 12(6):467-94.

Cohen EP, Bastani B, Cohen MR, Kolner S, Hemken P, Gluck SL. Absence of H(+)-ATPase in cortical collecting tubules of a patient with Sjogren's syndrome and distal renal tubular acidosis. J Am Soc Nephrol. 1992 Aug; 3(2):264-71.

Gluck SL. The structure and biochemistry of the vacuolar H+ ATPase in proximal and distal urinary acidification. J Bioenerg Biomembr. 1992 Aug; 24(4):351-9.

Wang ZQ, Hemken P, Menton D, Gluck S. Expression of vacuolar H(+)-ATPase in mouse osteoclasts during in vitro differentiation. Am J Physiol. 1992 Aug; 263(2 Pt 2):F277-83.

Marushack MM, Lee BS, Masood K, Gluck S. cDNA sequence and tissue expression of bovine vacuolar H(+)-ATPase M(r) 70,000 subunit. Am J Physiol. 1992 Jul; 263(1 Pt 2):F171-4.

Hemken P, Guo XL, Wang ZQ, Zhang K, Gluck S. Immunologic evidence that vacuolar H+ ATPases with heterogeneous forms of Mr = 31,000 subunit have different membrane distributions in mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9948-57.

Zhang K, Wang ZQ, Gluck S. Identification and partial purification of a cytosolic activator of vacuolar H(+)-ATPases from mammalian kidney. J Biol Chem. 1992 May 15; 267(14):9701-5.

Nelson RD, Guo XL, Masood K, Brown D, Kalkbrenner M, Gluck S. Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. Proc Natl Acad Sci U S A. 1992 Apr 15; 89(8):3541-5.

Bastani B, Purcell H, Hemken P, Trigg D, Gluck S. Expression and distribution of renal vacuolar proton-translocating adenosine triphosphatase in response to chronic acid and alkali loads in the rat. J Clin Invest. 1991 Jul; 88(1):126-36.

Schuster VL, Fejes-Tóth G, Naray-Fejes-Tóth A, Gluck S. Colocalization of H(+)-ATPase and band 3 anion exchanger in rabbit collecting duct intercalated cells. Am J Physiol. 1991 Apr; 260(4 Pt 2):F506-17.

Rodman JS, Stahl PD, Gluck S. Distribution and structure of the vacuolar H+ ATPase in endosomes and lysosomes from LLC-PK1 cells. Exp Cell Res. 1991 Feb; 192(2):445-52.

Wang ZQ, Gluck S. Isolation and properties of bovine kidney brush border vacuolar H(+)-ATPase. A proton pump with enzymatic and structural differences from kidney microsomal H(+)-ATPase. J Biol Chem. 1990 Dec 15; 265(35):21957-65.

Blair HC, Teitelbaum SL, Ghiselli R, Gluck S. Osteoclastic bone resorption by a polarized vacuolar proton pump. Science. 1989 Aug 25; 245(4920):855-7.

Alper SL, Natale J, Gluck S, Lodish HF, Brown D. Subtypes of intercalated cells in rat kidney collecting duct defined by antibodies against erythroid band 3 and renal vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1989 Jul; 86(14):5429-33.

Brown D, Hirsch S, Gluck S. Localization of a proton-pumping ATPase in rat kidney. J Clin Invest. 1988 Dec; 82(6):2114-26.

Aithal HN, Walsh-Reitz MM, Kartha S, Gluck SL, Franklin WA, Knigge KM, Toback FG. Kinetics of a novel cytosolic protein during the onset of renal epithelial cell growth. Am J Physiol. 1988 Nov; 255(5 Pt 2):F868-73.

Hirsch S, Strauss A, Masood K, Lee S, Sukhatme V, Gluck S. Isolation and sequence of a cDNA clone encoding the 31-kDa subunit of bovine kidney vacuolar H+-ATPase. Proc Natl Acad Sci U S A. 1988 May; 85(9):3004-8.

Yurko MA, Gluck S. Production and characterization of a monoclonal antibody to vacuolar H+ATPase of renal epithelia. J Biol Chem. 1987 Nov 15; 262(32):15770-9.

Gluck S, Caldwell J. Immunoaffinity purification and characterization of vacuolar H+ATPase from bovine kidney. J Biol Chem. 1987 Nov 15; 262(32):15780-9.

Brown D, Gluck S, Hartwig J. Structure of the novel membrane-coating material in proton-secreting epithelial cells and identification as an H+ATPase. J Cell Biol. 1987 Oct; 105(4):1637-48.

Gluck S, Al-Awqati Q. An electrogenic proton-translocating adenosine triphosphatase from bovine kidney medulla. J Clin Invest. 1984 Jun; 73(6):1704-10.

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